Maternal Nutritional Status and Pancreatic Beta Cell Function in Asian Indian Infants
Principal investigator:
Amount:$4000
Funding Source: Center for Chronic Disease Control ( CCDC), New Delhi.
Objective:
To examine the association of maternal nutritional status [i.e., first trimester body mass index (BMI); and pregnancy weight gain] with beta cell function of their infants at 6-months of age. Outcome measures will be collected at two time points: birth and 6-months postpartum. At birth, cord blood will be analyzed for glucose, c-peptide, and insulin and will be used to calculate maternal and fetal glycemia, insulin resistance, static insulin secretion, and insulin clearance. At 6 months of age, infants will undergo an oral glucose tolerance test, with samples analyzed for glucose, C-peptide, and insulin to assess pancreatic beta-cell function, measured by the oral disposition index. Other calculated measures at 6 months will include insulin resistance, static insulin secretion, and insulin clearance.
Status of the project:
A total of 150 women were included and cord blood was collected from them for analysis of glucose, insulin and c-peptide. A total of 1 30 infants were followed up at 8 months and venous blood was collected for analysis of glucose, insulin and c-peptide. Analysis of cord blood for insulin and c-peptide was done for 52 cases.